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En stor mengde information fra gravide indikerer hverken misdannelser eller toksisitet av paracetamol hos foster/nyfødt barn. Paralgin forte/Paralgin main skal bare brukes less than graviditet hvis fordel oppveier mulig risiko, og da med lavest mulig effektiv dose i kortest mulig tid og lavest mulig frekvens.
Kodein er et opioid som omdannes til morfin. Den smertelindrende virkningen til kodein skyldes binding til μ-opioidreseptorer.
Stoff som reduserer eller opphever virkningen av et annet stoff i organismen. Brukes ved behandling av overdosering/forgiftninger.
Pregnancy and Breast-feeding Talk to your medical professional in advance of getting the tablets In case you are Expecting or Feel you may well be pregnant.
Codeine The consequences in overdosage will probably be potentiated by simultaneous ingestion of alcohol and psychotropic drugs.
This drug is assessed for a pregnancy Group C drug. There won't be any satisfactory and nicely-managed research accomplished in pregnant Females. Codeine should only be utilized for the duration of pregnancy In case the likely benefit outweighs the probable danger on the drug to your fetus . Codeine has revealed embryolethal and fetotoxic consequences while in the hamster, rat as well as mouse types at about two-four times the maximum proposed human dose .
Codeine is really a centrally acting weak analgesic. Codeine exerts its influence through μ opioid receptors, Whilst codeine has lower affinity for these receptors, and its analgesic influence is due to its conversion to morphine.
There are some reviews of blood dyscrasias which includes thrombocytopenia and agranulocytosis, but there were not automatically causally connected with paracetamol.
The reduction of ache (analgesia) is really a Major goal for boosting the quality of life of individuals and for increasing the flexibility of individuals to engage in everyday actions. Codeine, an opioid analgesic, was at first authorised while in the US in 1950 and is also a drug utilized to reduce suffering by increasing the threshold for ache without the need of impairing consciousness or altering other sensory capabilities. Opiates including codeine are derived with the poppy plant, Papaver somniferum (Papaveraceae).
Maternally poisonous doses which were about 7 times the most advisable human dose of 360 mg/day, have been associated with evidence of bone resorption and more info incomplete bone ossification. Codeine did not exhibit proof of embrytoxicity or fetotoxicity within the rabbit design at doses as many as two periods the most proposed human dose of 360 mg/working day based on a physique area area comparison . Nonteratogenic effects
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Codeine is secreted into human milk. The maternal usage of codeine can possibly produce serious adverse reactions, like Dying, in nursing infants .
Høye doser av morfin vil kunne gjenfinnes i morsmelken etter sammenhengende bruk utover to uker. Bruk av kodeinholdige preparater hos slike kvinner anbefales ikke
Codeine phosphate hemihydrate (a by-product of Codeine) is described being an ingredient of Paralgin Forte in the following nations around the world: